Table 1.
Overview of rabbit vaccinations
| Group | Numbers of rabbits | Delivery modea | Plasmid-encoded immunogens | Expression vector | Dose/vaccination | Diluent, volume/vaccination | Time of vaccination |
|---|---|---|---|---|---|---|---|
| I | 4 | i.d. needle + EP | HA(H1N1)pdm09 | pSSI (3665 bp) | 10 pmol (200 μg) | PBS, 0.1 ml | Week 0, 3 |
| NA(H1N1)pdm09 | |||||||
| NP(H1N1)1918 | |||||||
| M(H1N1)1918 | |||||||
| HA(H3N2)1968 | |||||||
| NA(H3N2)1968 | |||||||
| II | 5 | IDAL | Same as Group I | pSSI (3665 bp) | 10 pmol (200 μg) | Diluvac®Forte, 0.4 ml | Week 0, 3 |
| III | 5 | IDAL | Same as Group I | NTC8385-VA1 (3025 bp) | 10 pmol (175 μg) | Diluvac®Forte, 0.4 ml | Week 0, 3 |
| IV | 5 | IDAL | Same as Group I | NTC9385R (1700 bp) | 10 pmol (125 μg) | Diluvac®Forte, 0.4 ml | Week 0, 3 |
a EP: electroporation, IDAL: IntraDermal Application of Liquids.