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. 2015 Jun 2;11(9):2215–2222. doi: 10.1080/21645515.2015.1052352

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Yuan-kai Wang, Ya-xian Yan, Hyeun Bum Kim, Xianghong Ju, Song Zhao, Keshan Zhang, Saul Tzipori, and Xingmin Sun

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 8. — Protective response of mTcd138 vaccination in hamsters. (A) Serum anti-TcdA/TcdB IgG titers after each immunization with mTcd138 (10 µg, IP); (B) Serum (from 3^rd immunization) anti-TcdA neutralizing titers; (C) Serum (from 3^rd immunization) anti-TcdB neutralizing titers; (D) Kaplan-Meier survival curves of mTcd138-immunized or PBS-immunized hamsters challenged with 2 × 10⁵ C. difficile UK6 spores (P = 0.0075).