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Phosphatase and tensin homolog (PTEN) is activated on Keratoacanthomas and inversely correlates with tumor cell proliferation. (A) Keratoacanthoma tumor cells and non-tumor epithelium were analyzed for nuclear Ki-67. (B) Representative example of Ki-67 staining in keratoacanthomas (Ki-67 IHC - 200×). C. Representative example of PTEN stain in keratoacanthomas (PTEN IHC - 200×). (D) Graphic representation of decreased proliferation in keratoacanthomas positive for PTEN (∗∗P ≤ 0.01).
