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. 2015 Jul 9;11(8):1961–1971. doi: 10.1080/21645515.2015.1066051

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Figure 3. — Monovalent and trivalent vaccination with BoNT/Hc/A, BoNT/Hc/B, and BoNT/Hc/E induces strong humoral immunity in mice. For the monovalent study, BALB/c mice received two 10 μg DNA immunizations spaced 3 weeks apart and sera were collected 3 weeks post-final immunization. Anti-botulinum neurotoxin titers against serotypes A (A), B (B), and E (C) for 5 animals per group were measured by ELISA. For the trivalent study, BALB/c mice (n = 5/group) received two 30 μg DNA immunizations (10 μg of each BoNT Hc construct) spaced 3 weeks apart and sera were collected 3 weeks post-final immunization. Anti-botulinum neurotoxin titers against serotypes A (D), B (E), and E (F) were measured by ELISA. Geometric mean and 95% confidence intervals are shown.