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Sclerostin activates PLCγ, PKC, Akt and ERK1/2 signaling in C3H10T1/2 and MC3T3-E1 cells. (a) C3H10T1/2 and (b) MC3T3-E1 cells were exposed to 10 μg ml−1 sclerostin for various incubation times before analysis of signaling proteins by western blotting. The arrows show a protein of approximately 130 kDa, which is phosphorylated on tyrosine residues in response to sclerostin. ERK, extracellular signal-regulated kinase; PKC, protein kinase C; PLCγ, phospholipase Cγ.
