Table 1.
Molecular ratio | DNA dose (in mg) |
Env protein |
||||||
---|---|---|---|---|---|---|---|---|
Group | N | env:gag DNA | SIV gag | SIV env | HIV env | Env in DNA vaccine | SIV | HIV |
1 | 16 | 1:1 | 0.5 | 0.5 | gp160 | none | ||
2 | 4 | 3:1 | 1 | 3 | gp160 | none | ||
3 | 16 | 3:1 | 1 | 3 | gp160 (N = 4) gp160 and gp120 (N = 12) | 100 μg | ||
4 | 6 | 1:1 | 1 | 1 | gp160 and gp140 | none | ||
5 | 9 | 3:1 | 1 | 3 | gp160, gp140 and gp120 | none | ||
6 | 25 | 3:1 | 1 | 3 | gp160 and gp120 (N = 9)gp120 (N = 16) | 100 μg |