Table 1.

Summary of the benefits of combination vaccines

Benefits	References
Societal
For children
Improve compliance and timeliness	1,25–32
Decrease potential local adverse events	33,34
Decrease pain and discomfort	35-37
For parents
Better acceptance and willingness to pay	34,37
Reduce time loss and productivity loss	36
For healthcare providers
Improve daily practice efficiency	4,36,38–41
Decrease risk of needle stick injuries and handling issues	29,42-44
Public health and economic
Alleviate vaccination calendars	28,35,38,46–48
Increase vaccination coverage rates	16,49,50
Decrease costs for the healthcare system	34,51-56