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. 2015 Aug 17;4(12):e1052931. doi: 10.1080/2162402X.2015.1052931

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Xiaohu Zheng, Zhigang Tian, and Haiming Wei

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — LunX binds to 14–3–3 and facilitates their activation by maintaining these proteins in a dephosphorylated and dimeric state, thereby contributing to the activation of pathways downstream of 14–3–3, such as the Erk1/2 and JNK pathways. As a result, LunX promotes lung cancer growth, metastasis and invasion. LunX antibody suppresses growth, metastasis and invasion of lung cancer cells by inducing LunX protein down-regulationdownregulation and blocking its downstream pathways.