Figure 6.

The newborn mice protection with pretreated anti-EV71 VLPs serum against EV71 lethal challenge in vivo. Serially diluted anti-EV71 serum (NTAb titer 4096) or PBS serum (NTAb titer <8 ) was incubated with 15LD₅₀ of the EV71 challenge virus at 37°C for 1 h. One-day-old ICR mice (n = 8–10 per group) were i.c. injected with the serum-virus mixture. Mortality and clinical disease were monitored and recorded daily after infection. The Mantel-Cox log-rank test was used to compare the survival of pups between each antiserum group and the PBS control group at 21 d post-infection. ***, P < 0.0001; **, P < 0.001.