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High doses of anti-CTLA-4 mAb can completely abrogate (T)cell suppression mediated by tumor-infiltrating Treg. The effect of higher doses of anti-CTLA-4 mAb on Treg-mediated suppression was tested using lymphocytes isolated from three different LM-CRC patients. T cell proliferation analysis revealed that higher doses of the neutralizing anti-CTLA-4 antibody are able to completely abolish the suppression mediated by tumor-infiltrating Treg.
