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IHC evidence of the involvement of P2X7R and P2Y1R in the regulation of pp38 expression. Intrathecal applications of the P2X7R antagonist, A740003 (A74) (250 nM) or the P2Y1R antagonist MRS (60 µM) at 10 µl, twice a day for 3 days, significantly inhibited the percentage of pp38 positive neurons in DRGs (Control: 20.40 ± 3.10 %, A740003: 8.00 ± 3.33 % and MRS: 1.93 ± 1.93 %) calibration bar: 50 µm, n = 3, *P < 0.05 compared with control
