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. 2015 Nov 5;11:68. doi: 10.1186/s12990-015-0073-7

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© Chen et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — A schematic shows the involvement of p38 in P2X7R-P2Y1R-P2X3R inhibitory control. Activation of P2X7R-P2Y1R leads to the activation of p38 in DRG neurons. p38 down-regulates P2X3Rs and results in reduction of nociception