Table 1.
Comparison between the parasite viability kinetic assay and the in vitro killing rate assay based on limiting dilutions using compounds from the Medicines for Malaria Venture Malaria Box
| Compound | In vitro killing rate assay (standard assay) | Viability assay (fast assay) |
|---|---|---|
| MMV000478 | Fast | Fast |
| MMV665939 | Slow | Slow |
| MMV019066 | Slow | Slow |
| MMV019662 | Slow | Slow |
| MMV007564 | Moderate | Fast/moderate |
| MMV020750 | Moderate | Moderate |
| MMV665789 | Moderate | Moderate |
| MMV665928 | Fast | Fast |
| MMV006767 | Moderate | Moderate |
| MMV008149 | Slow | Slow |
| MMV009108 | Slow | Slow |
| MMV665924 | Fast | Fast |
| MMV011895 | Fast | Fast |
| MMV019017 | Fast | Fast |
| MMV009063 | Fast | Fast |
| MMV665794 | Moderate | Moderate |
| MMV665824 | Slow | Slow |
| MMV006455 | Fast | Fast |
| MMV665852 | Moderate/fast | Fast |
| MMV665888 | Moderate | Moderate |
Fast chloroquine/artemisinin-like (no viable parasites detected after 24 h’ treatment), moderate pyrimethamine-like (no viable parasites detected after 48 h’ treatment), slow atovaquone-like (more than 48 h’ treatment needed to kill all parasites)