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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Nat Chem Biol. 2015 Sep 21;11(11):870–877. doi: 10.1038/nchembio.1926

Figure 1. Architecture of the modular Type ISP RM enzymes.

Figure 1

a, Surface representation of LlaBIII-DNA. b, Superposition of the two chains of LlaBIII reveals conformational plasticity. The coupler domain (residues 715 to 870) of Chain B (grey) was superimposed onto the coupler domain of chain A using the Secondary-structure matching method in Coot.52 The structural domains of Chain A are coloured as in Fig. 1b. The hinge about which the nuclease-ATPase domains move with respect to the coupler is indicated (Supplementary Table 1).