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. 2015 Nov 2;8:3185–3192. doi: 10.2147/OTT.S82453

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© 2015 Cheng et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The synergistical efficacy of CTX plus PP242 against proliferation and invasiveness of wild-KRAS CRC cells.

Notes: (A) Colony formation assay of control group and Caco-2 cells treated with CTX and/or PP242. (B) The colony numbers in A were accounted and presented as mean + SD. The combination treatment showed the most prominent efficiency against colony formation when compared with other groups. (C) Caco-2 cells were seeded on a Matrigel-coated transwell membrane, and the treatment and analysis were similar to the colony formation assay. (D) The cell numbers invading through the membrane into the lower compartment of the chamber were counted as mean + SD.

Abbreviations: CTX, cetuximab; CRC, colorectal cancer; SD, standard deviation.