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. 2015 Nov 2;8:3185–3192. doi: 10.2147/OTT.S82453

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© 2015 Cheng et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The efficacy of CTX plus PP242 against tumor xenografts.

Notes: (A) After inoculation of Caco-2 cells, CTX (20 mg/kg) and PP242 (50 mg/kg) was injected into nude mice twice a week for 14 days. The body weight was measured every day, and the tumor volumes were analyzed. The treatment efficiency of CTX plus PP242 was distinguished from other groups, and the synergistic efficient was gradually increased as time went on. (B) The combination treatment had no significant effects on the body weight of mice during the treatments. (C) Representative figure of subcutaneous tumors from all groups. Tumors were most sensitive to the combination of PP242 and CTX when compared with other groups.

Abbreviation: CTX, cetuximab.