DOMAIN	21 ITEMS THAT UNDERWENT COGNITIVE INTERVIEWING	FINAL VERSION OF THE 21-ITEM SCREENER APPLICABLE ACROSS ALL CANCER AND TREATMENT TYPES
Agenda Setting for Visit	“What would you like to talk to nurse or doctor about today?”3	What would you like to talk to nurse or doctor about today?
Insomnia	What was the SEVERITY of your INSOMNIA (INCLUDING DIFFICULTY FALLING ASLEEP, STAYING ASLEEP, OR WAKING UP EARLY) at its WORST?1	Rate your worst insomnia (trouble sleeping).
Decreased Appetite	What was the SEVERITY of your DECREASED APPETITE?1	Rate your worst decreased appetite.
Nausea	What was the SEVERITY of your NAUSEA at its WORST?1	Rate your worst upset stomach.
Pain Frequency	How OFTEN did you have PAIN?1	How often did you have pain?
Pain Intensity	What was the SEVERITY of your PAIN at its WORST?1	Rate your worst pain.
Depression	What was the SEVERITY of your SAD or UNHAPPY FEELINGS at their WORST?1	Rate your worst sad or unhappy feelings.
Fatigue	What was the SEVERITY of your FATIGUE, TIREDNESS, OR LACK OF ENERGY at its WORST?1	Rate your worst tiredness, lack of energy, fatigue.
Headache	What was the SEVERITY of your HEADACHE at its WORST?1	Rate your worst headache.
Anxiety	What was the SEVERITY of your ANXIETY at its WORST?1	Rate your worst anxiety (worrying).
Neuropathy	What was the SEVERITY of your NUMBNESS OR TINGLING IN YOUR HANDS OR FEET at its WORST?1	Rate your worst numbness or tingling in your hands or feet.
Dyspnea	What was the SEVERITY of your SHORTNESS OF BREATH?1	Rate your worst shortness of breath.
Cough	What was the SEVERITY of your COUGH at its WORST?1	Rate your worst cough.
Trouble Concentrating	What was the SEVERITY of your PROBLEMS WITH CONCENTRATION at their WORST?1	Rate your worst problems with concentration.
Diarrhea	How OFTEN did you have LOOSE OR WATERY STOOLS (DIARRHEA)?1	How often did you have loose or watery stools (diarrhea).
Loss of control of urine	How OFTEN did you have LOSS OF CONTROL OF URINE (LEAKAGE)? 1	How often did you have loss of control of urine (leakage).
Rash	Did you have any RASH?1	Did you have a rash? (yes/no)
Other Symptoms Not Listed	Did you have any other symptoms not listed?3	Did you have any other symptoms not listed?
Overall Health	In general, would you say your HEALTH is:2 Excellent, Very Good, Good, Fair, Poor?	In general, would you say your health is: Excellent, Very Good, Good, Fair, Poor?
Quality of Life	In general, would you say your QUALITY OF LIFE is:2 Excellent, Very Good, Good, Fair, Poor?	In general, would you say your quality of life is: Excellent, Very Good, Good, Fair, Poor?
Daily Activities	To what extent are you able to carry out your everyday physical activities such as walking, climbing stairs, carrying groceries, or moving a chair?2	To what extent are you able to carry out your everyday physical activities such as walking, climbing stairs, carrying groceries, or moving a chair?

Notes:

¹PRO-CTCAE,

²PROMIS Global Health Questionnaire,

³Question Written by Authors.