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. Author manuscript; available in PMC: 2015 Nov 6.
Published in final edited form as: Mol Cell Neurosci. 2006 Apr 19;32(0):82–90. doi: 10.1016/j.mcn.2006.02.004

Table 3.

Functional consequences of SCCMS mutations

AChR type (αβδε) Expression level (fmol) EC50 (µM) Hill coefficient Normalized response (−nA/fmol
Wild type 2.3 ± 0.5 54 ± 1 1.4 ± 0.5 800 ± 300
βV229F 1.4 ± 0.4 5.5 ± 1* 1.3 ± 0.5 2800 ± 700*

Values are given as the mean ± SEM. Normalized peak channel activity for individual oocytes was obtained by dividing the ACh-induce current at 300 µM by the fmol of AChR expressed on each oocyte. AChR expression levels, EC50, Hill coefficients and normalized responses were calculated using 7 – 13 oocytes.

*

P < 0.05.