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. 2015 Sep;10(18):2805–2818. doi: 10.2217/nnm.15.105

Figure 2. . Synthetic scheme for synthesis of lipids 4 and 5.

Figure 2. 

Conditions: a. N-hydroxyphthalimide, PPh3, DIAD, 0 °C to rt, 12h; b. N2H4•H2O, CH2Cl2, rt, 2.5h (16%, 2 steps); c. tetradecyl aldehyde (for 9) or oleyl aldehyde (for 11), CH2Cl2, rt, 10h (47–71%); d. TFA, CH2Cl2, 0 °C to rt, 3h (91–100%); e. glycidol, EtOH, rt, ca. 2.5d (38–41%); f. CH3I, CH2Cl2 (sealed tube), 55 °C, 18h (63–64%).