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. 2015 Nov 6;10(11):e0142347. doi: 10.1371/journal.pone.0142347

Fig 1. Blood-brain barrier disruption and brain pharmacokinetics of PGUS at two doses of epinephrine.

Fig 1

(A) shows that the 120 nmol/mouse dose of epinephrine decreased the vascular space of I-Alb. (B) shows that neither dose disrupted the BBB. (C) shows that both doses reduced vascular space of I-PGUS and that the 120 nmol/mouse dose also slowed clearance from blood. (D) shows that I-PGUS did not cross the BBB, but that both doses of epinephrine induced transport of I-PGUS across the BBB. n = 7/group.