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. 2015 Nov 6;10(11):e0141660. doi: 10.1371/journal.pone.0141660

Fig 1. Markov State-transition decision model for Hepatitis C and liver disease: The model consists of two phases: treatment and natural history.

Fig 1

If patients discontinue treatment due to adverse events or fail to respond and hence not achieve SVR, they enter the natural history component of the model, consisting of 15 health states: Fibrosis states (F0–F4); decompensated cirrhosis first (DC1) and subsequent years (DC2); hepatocellular carcinoma first (HCC1) and subsequent years (HCC2); liver transplant first (LT1) and subsequent years (LT2); disease specific mortality; mortality from all other causes (not shown); and SVR status states stratified by fibrosis stage (“SVR F0-F2”, “SVR-F3”, SVR-F4). For clarity, only liver transplant is stratified by state year. This figure is similar but not identical to the original image, and is therefore for illustrative purposes only.