Table 1. Demographic and Clinical Characteristics of 48 PVAN Patients according to the Pathologic Class.
| Class A (n = 11) | Class B (n = 31) | Class C (n = 6) | P value | |
|---|---|---|---|---|
| Age at transplant | 36±7 | 39±12 | 41±13 | 0.609 |
| Male gender [n(%)] | 10(90.9) | 15(48.4) | 4(66.7) | 0.044 |
| Living donor[n(%)] | 3(27.3) | 6(19.4) | 1(16.7) | 0.827 |
| Immunosuppressive Regimen | ||||
| Anti-IL-2R [n(%)] | 7(63.6) | 9(29.0) | 3(50.0) | 0.112 |
| ATG [n(%)] | 7(63.6) | 22(71.0) | 2(33.3) | 0.210 |
| Tac -MPA[n(%)] | 10(90.9) | 30(96.8) | 6(100) | 0.607 |
| Complications | ||||
| AR before PVAN[n(%)] | 3(27.3) | 10(32.3) | 4(66.7) | 0.221 |
| DGF[n(%)] | 0(0) | 3(9.7) | 0(0) | 0.416 |
| Severe pneumonia [n(%)] | 2(18.2) | 5(16.1) | 3(50.0) | 0.169 |
| Diagnosis of PVAN | ||||
| Time posttransplant (m) | 11±6 | 16±12 | 15±3 | 0.376 |
| Biopsy performed for BKV surveillance | 9(81.8) | 7(22.6) | 0(0) | <0.001 |
| Decoy cells(/10 HPF) | 23(2–85) | 43(0–125) | 17(0–35) | 0.015 |
| BKV DNAuria (copies /ml) | 1.38 ×107(1.00×105−9.00×1010) | 6.00×109(8.10×105−1.20×1012) | 4.92×108(0–6.00×1010) | 0.030 |
| BK viremia(copies /ml) | 1.60 ×104(0–1.22×105) | 5.34 ×104(0–5.20×106) | 8.49×102(0–2.25×105) | 0.079 |
| Histologic finding at diagnosis | ||||
| cy score | 1.09±0.3 | 1.71±0.9 | 1.67±0.5 | 0.065 |
| i score | 0.18±0.4 | 1.61±0.5 | 2.50±0.5 | <0.001 |
| ct score | 0.36±0.7 | 1.48±0.6 | 2.33±0.8 | <0.001 |
| ci score | 0.18±0.4 | 1.29±0.7 | 2.50±0.6 | <0.001 |
Anti-IL-2R, monoclonal antibody to the IL-2 receptor; ATG, Anti-thymocyte globulin