Table 2. 1-year and Long-term Graft Outcome, BKV Reduction and Clearance of PVAN Classified as A, B or C after Modification of Maintenance Immunosuppression.
| A (n = 11) | B (n = 31) | C (n = 6) | P value | |
|---|---|---|---|---|
| Graft outcome | ||||
| Scr at diagnosis (umol/L) | 164.6±36.1 | 181.9±58.1 | 369.7±158.7 | <0.001 |
| Graft loss 1 year after diagnosis[n(%)] | 0(0) | 2(6.5) | 4(66.7) | <0.001 |
| Any graft functional decline 1 year after diagnosis [n(%)] | 1(9.1) | 8(25.8) | 4(66.7) | 0.037 |
| Scr 1 year after diagnosis(umol/L) | 165.5±85.3 | 203.0±108.8 | 363.0±84.9 | 0.052 |
| Graft loss at the latest follow-up[n(%)] | 0(0) | 7(22.6) | 5(83.3) | 0.001 |
| Any graft functional decline at the latest follow-up [n(%)] | 1(9.1) | 10(32.3) | 5(83.3) | 0.008 |
| Scr at the latest follow-up(umol/L) | 168.2±88.3 | 177.5±95.0 | 486.0±0 | 0.009 |
| Reduction of BKV replication by 90% [n(%)] | ||||
| BKV DNAuria | 10/11(90.9) | 26/31(83.9) | 2/4(50.0) | 0.002 |
| BK viremia | 9/10 (90.0) | 25/28 (89.3) | 1/3(33.3) | 0.024 |
| Clearance of BKV replication [n(%)] | ||||
| Decoy cells | 10/11(90.9) | 17/30 (56.7) | 2/5(40.0) | 0.070 |
| BKV DNAuria | 7/11 (63.6) | 5/31 (16.1) | 1/4(25.0) | <0.001 |
| BK viremia | 9/10(90.0) | 23/28(82.1) | 1/3(33.3) | 0.039 |