Table 3.

Statistically Significant Categorical Predictions in TONE by Individual Polymorphisms/Genes/Pathways and Related Previously Reported Associations

Polymorphism	Gene/Pathway	SBP Weight Sensitivity	DBP Weight Sensitivity	SBP Salt Sensitivity	DBP Salt Sensitivity	Gene/Pathway	Reference #
rs4684847	PPAR-γ			0.004		PPAR-γ	27
rs6997709	KCNK9			0.003		TGF-β and K+	28
rs1800629	TNF-α	0.018				TNF-α and insulin resistance	29
rs2820037	RYR2	0.002	0.005			RYR2 and hypertension	30
rs4646994	ACE	0.01	0.004			ACE	31
rs5744292	IL-18		0.0001		0.005	IL-18 and hypertension and sudden death	32
rs7961152	BCAT1				0.03	BCAT1 and salt sensitivity	33

DBP indicates diastolic blood pressure; and SBP, systolic blood pressure.

P values correspond to a single polymorphism model adjusting for the basic covariates.