Table 4. Peripheral NK-cells, T-cells and naive T-cells per CHARGE patient.
| Patient | NK-cells 1 | CD3+ T-cells 1 | CD4+ T-cells 1 | Naive mature CD4+ T-cells 2 | Naive mature CD4+ T-cells 2 | CD8+ T-cells 1 | Naive mature CD8+ T-cells 2 | Naive mature CD8+ T-cells 2 |
|---|---|---|---|---|---|---|---|---|
| CD16+56+ | CD45+ CD3+ | CD3+ CD4+ | CD45R0- CCR7+ CD27+ CD28+ | CD45R0- CCR7+ CD27+ CD28+ | CD3+ CD8+ | CD45R0- CCR7+ CD27+ CD28+ | CD45R0- CCR7+ CD27+ CD28+ | |
| CHD01 | 261 (100–700) | 1628 (1000–2000) | 884 (500–1300) | 527 (277–796) | 59.6% (42.4–66.3) | 578 (300–800) | 396 (205–465) | 68.5% (48.8–72.9) |
| CHD02 | 584 (100–600) | 1755 (1100–2800) | 1209 (500–1800) | 800 (515–913) | 66.2% (60.2–74.6) | 446 (400–1200) | 261 (369–578) | 58.6% (49.1–78.8) |
| CHD04 | 117 (100–700) | 2010 (1400–3600) | 1322 (700–2000) | 1000 (n/a) | 75.7% (n/a) | 500 (500–1400) | 405 (n/a) | 81.1% (n/a) |
| CHD05 | 88 (100–700) | 1641 (1000–2000) | 1001 (500–1300) | 629 (277–796) | 62.8% (42.4–66.3) | 452 (300–800) | 273 (205–465) | 60.3% (48.8–72.9) |
| CHD06 | 110 (100–400) | 1110 (700–1900) | 610 (400–1300) | 338 (277–796) | 55.4% (42.4–66.3) | 250 (200–700) | 147 (205–465) | 58.6% (48.8–72.9) |
| CHD08 | 230 (100–700) | 1285 (1000–2000) | 732 (500–1300) | 394 (277–796) | 53.8% (42.4–66.3) | 392 (300–800) | 229 (205–465) | 58.4% (48.8–72.9) |
| CHD09 | 467 (100–700) | 1458 (1400–3600) | 862 (700–2000) | 553 (n/a) | 64.2% (n/a) | 417 (500–1400) | 325 (n/a) | 77.9% (n/a) |
| CHD10 | 957 (100–700) | 2546 (1400–3600) | 1488 (700–2000) | 1019 (n/a) | 68.5% (n/a) | 813 (500–1400) | 236 (n/a) | 29.1% (n/a) |
| CHD11 | 234 (100–700) | 1282 (1000–2000) | 845 (500–1300) | 488 (277–796) | 57.8% (42.4–66.3) | 340 (300–800) | 198 (205–465) | 58.4% (48.8–72.9) |
| CHD12 | 182 (100–600) | 1374 (1100–2800) | 915 (500–1800) | 390 (515–913) | 42.7% (60.2–74.6) | 357 (400–1200) | 115 (369–578) | 32.2% (49.1–78.8) |
| CHD13 | 372 (100–600) | 2192 (1100–2800) | 1269 (500–1800) | 814 (515–913) | 64.2% (60.2–74.6) | 652 (400–1200) | 247 (369–578) | 37.9% (49.1–78.8) |
| CHD14 | 330 (100–600) | 899 (1100–2800) | 458 (500–1800) | 215 (515–913) | 47.0% (60.2–74.6) | 297 (400–1200) | 87 (369–578) | 29.3% (49.1–78.8) |
| CHD15 | 172 (100–700) | 1110 (1000–2000) | 787 (500–1300) | 490 (277–796) | 62.3% (42.4–66.3) | 250 (300–800) | 138 (205–465) | 55.5% (48.8–72.9) |
| CHD16 | 184 (100–700) | 1042 (1000–2000) | 308 (500–1300) | 111 (277–796) | 36.2% (42.4–66.3) | 649 (300–800) | 115 (205–465) | 17.7% (48.8–72.9) |
| CHD17 | 118 (100–700) | 1622 (1400–3600) | 894 (700–2000) | 691 (n/a) | 77.3% (n/a) | 520 (500–1400) | 79 (n/a) | 71.8% (n/a) |
| CHD18 | 219 (100–1100) | 1483 (2200–5500) | 1008 (1100–3600) | 725 (n/a) | 72.0% (n/a) | 373 (500–1800) | 310 (n/a) | 83.2% (n/a) |
| CHD19 | 303 (100–700) | 887 (1000–2000) | 507 (500–1300) | 250 (277–796) | 49.3% (42.4–66.3) | 230 (300–800) | 94 (205–465) | 41.0% (48.8–72.9) |
| CHD20 | 580 (100–600) | 940 (1100–2800) | 400 (500–1800) | 138 (515–913) | 34.5% (60.2–74.6) | 290 (400–1200) | 73 (369–578) | 25.1% (49.1–78.8) |
| CHD21 | 187 (100–700) | 1455 (1000–2000) | 917 (500–1300) | 654 (277–796) | 71.4% (42.4–66.3) | 417 (300–800) | 310 (205–465) | 74.6% (48.8–72.9) |
| CHD22 | 354 (100–700) | 1431 (1400–3600) | 1035 (700–2000) | 602 (n/a) | 58.1% (n/a) | 182 (500–1400) | 102 (n/a) | 56.2% (n/a) |
| CHD23 | 192 (100–600) | 1239 (1100–2800) | 734 (500–1800) | 495 (515–913) | 67.5% (60.2–74.6) | 365 (400–1200) | 265 (369–578) | 72.8% (49.1–78.8) |
| CHD25 | 98 (100–700) | 1404 (1400–3600) | 896 (700–2000) | 625 (n/a) | 69.7% (n/a) | 422 (500–1400) | 315 (n/a) | 74.7% (n/a) |
| CHD26 | 656 (100–700) | 1261 (1000–2000) | 775 (500–1300) | 511 (277–796) | 65.9% (42.4–66.3) | 342 (300–800) | 143 (205–465) | 41.9% (48.8–72.9) |
| CHD27 | 452 (100–700) | 606 (1000–2000) | 368 (500–1300) | 109 (277–796) | 29.5% (42.4–66.3) | 169 (300–800) | 7 (205–465) | 4.1% (48.8–72.9) |
1 Absolute numbers in cells/μl. Age-matched reference values are shown in brackets [13,15]. Values below the age-matched reference values are shown in bold.
2 Absolute numbers in cells/μl and relative numbers in percentages of naive mature CD4+ or CD8+ T-cells. Age-matched reference values are shown in brackets [15]. If both the absolute and the relative numbers are below the age-matched reference values, values are shown in bold.
n/a, age-matched reference value not available