Table 3.

Univariate Cox Regression Analyses of Disease-free and Overall Survival in Relation to Clinicopathologic Features

Characteristics	No. of patients	Disease-free Survival		Overall Survival
		HR (95% CI)	p value	HR (95% CI)	p value
Age (years)	398	0.99 (0.97 – 0.997)	0.02	1.00 (0.98 – 1.01)	0.47
Gender
Female (ref)	176	1.00		1.00
Male	222	1.16 (0.91 – 1.48)	0.22	1.20 (0.93 – 1.53)	0.16
Tumor differentiation
Well-Moderate (ref)	252	1.00		1.00
Poor	146	1.42 (1.11 – 1.81)	0.005	1.51 (1.18 – 1.93)	0.001
Margins
Negative (ref)	367	1.00		1.00
Positive	31	1.48 (0.97 – 2.25)	0.07	1.82 (1.20 – 2.76)	0.005
Pathologic tumor stage
ypT0–ypT2 (ref)	42	1.00		1.00
ypT3	356	2.43 (1.49 – 3.97)	<0.001	2.46 (1.50 – 4.02)	<0.001
AJCC Stage
IA–IB (ref)	35	1.00		1.00
IIA	148	2.35 (1.29 – 4.29)	0.005	2.29 (1.25 – 4.19)	0.007
IIB	215	3.98 (2.21 – 7.17)	<0.001	3.89 (2.16 – 7.00)	<0.001
HTRG
CAP grade 0/1 (ref)	63	1.00		1.00
CAP grade 2/3	335	1.99 (1.36 – 2.92)	<0.001	2.01 (1.37 – 2.95)	<0.001
Number of positive lymph nodes
0 (ref)	183	1.00		1.00
1–2	117	1.59 (1.19 – 2.13)	0.002	1.58 (1.17 – 2.12)	0.003
	98	2.52 (1.88 – 3.37)	<0.001	2.59 (1.93 – 3.49)	<0.001
Lymph Node Ratio
0 (ref)	183	1.00		1.00
0.19	162	1.70 (1.30 – 2.21)	<0.001	1.65 (1.25 – 2.16)	<0.001
LNR > 0.19	53	3.36 (2.36 – 4.78)	<0.001	3.69 (2.60 – 5.23)	<0.001

Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval; ref, reference; HTRG, histopathologic tumor response grade; LNR, lymph node ratio