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. 2015 Nov 6;5(11):e008861. doi: 10.1136/bmjopen-2015-008861

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Incremental cost-effectiveness plane. Incremental cost-effectiveness plane based on 10 000 Monte Carlo simulation iterations, which drew parameters for each input simultaneously from probability distributions. Incremental cost (2014£) is on the vertical axis and incremental efficacy (quality-adjusted life-years, QALYs) is on the horizontal axis. As depicted on the incremental cost-effectiveness plane, the probability of ranolazine being cost-effective was >99% (quadrants II and III), assuming a willingness-to-pay (WTP) threshold of £20 000/QALY. We estimated there was a 70.5% chance the addition of ranolazine to standard-of-care therapy would be a dominant economic strategy compared with standard-of-care alone (quadrant III).