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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Eur J Immunol. 2015 Aug 25;45(10):2742–2757. doi: 10.1002/eji.201545512

Figure 2.

Figure 2

Proposed schematic of intracellular immune response to murine norovirus (MNV) infection. MNV may infect macrophages or dendritic cells in the gut. Infected cells sense MNV via MDA-5 and produce IFNs through this or the STAT-1 pathway. Type I IFNs inhibit MNV uncoating via ISG15 and may inhibit replication complex formation via an Atg complex. Type II IFNs block MNV translation via RNA-activated protein kinase (PKR). VF1-related immune suppression by MNV is not included in this schematic.