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Residue Phe411 is substituted with Tyr in IMPDH-B and residue Tyr411 is substituted with Phe in IMPDH-A. nd, no data.
| IC50 (μM) | ||||
|---|---|---|---|---|
| WT | 411* | C-terminal swap | C-terminal + 411* | |
| PbIMPDH-A | 0.43 ± 0.03 | 0.16 ± 0.02 | 3 ± 0.2 | 4.1 ± 0.3 |
| PbIMPDH-B | 27 ± 9 | 25 ± 2 | 4.1 ± 0.3 | 3.1 ± 0.3 |
| AnImdA | 0.026 ± 0.002 | 0.026 ± 0.002 | nd | nd |
