Fig. 4.

miRNAs showing differential expression in porcine endometrium classified into various functions and pathways by Ingenuity Pathway Analysis (IPA). a Top molecular functions enriched with DE miRNAs for PD20 vs. CD20, PD20 vs. PD16, PD16 vs. CD16, PD16 vs. PD12 and CD16 vs. C12 comparisons. The X-axis represents score for the likelihood [−log (Benjamin-Hochberg p-value < 0.05)] that genes belonging to a specific function category are affected in the specific comparisons. b Networks representing molecules of interest differentially regulated in selected comparisons. The network is displayed graphically as nodes (miRNAs/genes/genes products) and edges (biological relationship between nodes). The node color intensity indicates the fold-change expression of miRNAs; with red representing up-regulation and green down-regulation of miRNAs. The log2 fold change value and FDR for individual miRNAs is indicated under each node. The shapes of nodes indicate the functional class of the gene product and the lines indicate the type of interaction, explained in the legend. All connections were integrated into the computationally generated networks on the basis of the evidence stored in the IPA knowledge memory indicating relevance for these networks