Table 2.
Genetic associations of rs3928672 with the lymph node metastasis of NPC
| Populations | Genotypes | N classification, n (%) | OR (95 % CI)a | P valuea | |||
|---|---|---|---|---|---|---|---|
| N0 | N1 | N2 | N3 | ||||
| Guangxi | (n = 177) | (n = 406) | (n = 180) | (n = 78) | |||
| GG | 91 (51.4) | 187 (46.1) | 95 (52.8) | 22 (28.2) | 1.00 (reference) | ||
| GA | 72 (40.7) | 177 (43.6) | 69 (38.3) | 47 (60.3) | 2.50 (1.47-4.25) | 0.0010 | |
| AA | 14 (7.9) | 42 (10.3) | 16 (8.9) | 9 (11.5) | 2.31 (1.01-5.27) | 0.046 | |
| GA + AA | 86 (48.6) | 219 (53.9) | 85 (47.2) | 56 (71.8) | 2.47 (1.47-4.13) | 0.00030 | |
| Guangdong | (n = 226) | (n = 372) | (n = 260) | (n = 65) | |||
| GG | 123 (54.4) | 184 (49.5) | 134 (51.5) | 25 (38.5) | 1.00 (reference) | ||
| GA | 87 (38.5) | 152 (40.8) | 105 (40.4) | 37 (56.9) | 1.95 (1.14-3.34) | 0.015 | |
| AA | 16 (7.1) | 36 (9.7) | 21 (8.1) | 3 (4.6) | 0.79 (0.23-2.72) | 0.71 | |
| GA + AA | 103 (45.6) | 188 (50.5) | 126 (48.5) | 40 (61.5) | 1.75 (1.03-2.98) | 0.034 | |
| Pooled | (n = 403) | (n = 778) | (n = 440) | (n = 143) | |||
| GG | 214 (53.1) | 371 (47.7) | 229 (52.0) | 47 (32.9) | 1.00 (reference) | ||
| GA | 159 (39.5) | 329 (42.3) | 174 (39.5) | 84 (58.7) | 2.22 (1.51-3.20) | 4.07 × 10−5 | |
| AA | 30 (7.4) | 78 (10.0) | 37 (8.5) | 12 (8.4) | 1.54 (0.79-2.99) | 0.21 | |
| GA + AA | 189 (46.9) | 407 (52.3) | 211 (48.0) | 96 (67.1) | 2.08 (1.44-3.01) | 8.60 × 10−5 | |
| Overallb | (n = 403) | (n = 778) | (n = 440) | (n = 143) | |||
| GG | 214 (53.1) | 371 (47.7) | 229 (52.0) | 47 (32.9) | 1.00 (reference) | ||
| GA | 159 (39.5) | 329 (42.3) | 174 (39.5) | 84 (58.7) | 2.21 (1.52-3.23) | 3.82 × 10−5 | |
| AA | 30 (7.4) | 78 (10.0) | 37 (8.5) | 12 (8.4) | 1.66 (0.83-3.29) | 0.15 | |
| GA + AA | 189 (46.9) | 407 (52.3) | 211 (48.0) | 96 (67.1) | 2.09 (1.44-3.03) | 9.64 × 10−5 | |
Note: Guangxi and Guangdong populations consist of 855 and 962 patients with known lymph node involvement (N classification) stage, respectively. Due to DNA quality and/or quantity, the actual sample sizes were 841 and 923 patients in the Guangxi and Guangdong population, respectively
Abbreviations: N lymph node involvement, OR odds ratio, CI confidence interval
aIn the Guangxi population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, smoking level, family history and nationality. In the Guangdong population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, and smoking level. In the pooled population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, and smoking level. Another confounding factor, native place, was also adjusted in the pooled population
bA meta-analysis combining two independent case–control studies. The P values for heterogeneity among sample sets are 0.52 for GA vs. GG group, 0.18 for AA vs. GG and 0.36 for GA + AA vs. GG group, respectively