Fig. 1.

Predicted miR-155 and miR-802 targets are enriched in neuronal functions by gene ontology analysis. a Schematic representation of human chromosome 21 long-arm comprised of mouse chromosomal segments from chromosomes 16, 17, and 10. The portion of chromosome 16 that is found in trisomy in the Ts65Dn mouse expands from Mrpl39 (mitochondrial ribosomal protein, human MRPL39) to Zfp295 (zinc finger protein 295, human ZNF295) and harbors miR-155 and miR-802. b Venn diagram of hsa-miR-155 and hsa-miR-802 miRWalk predicted targets. c Functional profiling of the resulting list of 752 commonly predicted miR-155 and miR-802 targets in brain was analyzed using DAVID Bioinformatic Resources. Left panel shows enrichment in gene ontology terms related to SP PIR keywords. Right panel shows enrichment in gene ontology terms related to cellular compartment