Table 1.
Clinical information and islet quality testing.
| Variable | Autoantibody-positive donors | Control donors | All non-diabetic donors |
|---|---|---|---|
| Total no. of donors | 32 | 32 | 969 |
| Age (range) | 52·6 (21–74) | 52·1 (22–72) | 55·6 (1–84) |
| Sex | |||
| Female | 13 (40%) | 13 (40%) | 414 (43%) |
| Male | 19 (60%) | 19 (60%) | 549 (57%) |
| Unknown | 0 | 0 | 6 (0·62%) |
| Known excessive alcohol consumption (no of donors) | 9 (28%) | 4 (13%) | n.a. |
| Number of islets at isolation | 201 000 (27 000–480 000) | 220 000 (39 000–660 000) | 210 000 (7600–760 000) |
| Body mass index | 25 (18–34·6) | 27·3 (20·8–45·7) | 26·1 (13·9–45·7) |
| HbA1c (%) | 5·7 (5·1–7)* | 5·6 (4·8–6·2) | 5·7 (4·2–10)* |
| HbA1c (mmol/mol) | 39 (32–53)* | 38 (29–44) | 39 (22–86)* |
| Total no. of donors with HLA information available | 31 | 30 | |
| DR4 | 3 (9.7%) | 10 (33%) | n.a. |
| DR3 | 12 (38%) | 7 (23%) | n.a. |
| Neither DR4 nor DR3 | 16 (52%) | 13 (43%) | n.a. |
| DQ8 | 0 (0%) | 2 (6.7%) | n.a. |
| DQ2 | 16 (52%) | 11 (37%) | n.a. |
| Neither DQ8 nor DQ2 | 15 (48%) | 17 (57%) | n.a. |
| DR4–DQ8 | 0 | 0 | n.a. |
| Insulin (pmol/μg DNA) | 4·3 (0·39–15) | 4·9 (0·30–15) | 5.1 (0·095–26) |
| Tissue factor (10−15 mol/μg DNA) | 54 (2·0–170) | 43 (8·0–190) | 53 (0–640) |
| Monocyte chemoattractant Protein-1 (10−15 mol/μg DNA) | 9·1 (2·0–23) | 9·2 (1·0 −45) | 10 (0–120) |
| Interleukin-6 (10−15 mol/μg DNA) | 4·3 (0·1–52) | 1·7 (0·2–4·4) | 2.9 (0–93) |
| Interleukin-8 (10−15 pmol/μg DNA) | 60 (4·0–250) | 37 (8·0–120) | 50 (0–630) |
*
Glycated haemoglobin (HbA1c) values > 6·5% (48 mmol/mol) were noted in 11 of 969 control donors, and in one autoantibody-positive donor without diabetes diagnosis. Range is shown in parentheses unless specified otherwise. HLA = human leucocyte antigen.