Table 4.
Frequency of CD8+ T cells, CD4+ T cells, neutrophils and regulatory T cells in exocrine tissue from the 12 donors with the highest numbers of CD45 cells in exocrine tissue. Average number of cells is calculated on the donors where the relevant immune cells are present.
| Autoantibody-positive donors with high CD45 density (n = 6) | Donors double-positive for GADA and IA-2A (n = 3) | Control donors (n = 6) | ||||
|---|---|---|---|---|---|---|
| Cell type | n (%) | Average no of cells/mm2 (s.d.) | n (%) | Average no of cells/mm2 (s.d.) | n (%) | Average no of cells/mm2 (s.d.) |
| CD8+ | 6 (100) | 33 (23) | 3 (100) | 47 (57) | 6 (100) | 52 (23) |
| CD4+ | 3 (50) | 1·6 (1.2) | 1 (33) | 2·0 (n.a.) | 3 (50) | 12 (16) |
| Neutrophils | 6 (100) | 1·4 (0.63) | 3 (100) | 9·2 (7·3) | 6 (100) | 13 (23) |
| Regulatory T cells | 3 (50) | 0·84 (0.61) | 2 (67) | 0·56 (0·63) | 2 (33) | 1.7 (0·88) |
GADA = glutamic acid decarboxylase antibodies; IA2A = islet antigen-2 antibodies; n.a. = not applicable; s.d. = standard deviation.