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Rate reduction and vaccine efficacy are time dependent variables. Time-to-event curves for acquisition of HPV6/11/16/18-related CIN3/AIS in Gardasil® (Merck & Co., Whitehouse Station, NJ USA) and placebo recipients in the ITT cohort. AIS: Adenocarcinoma in situ; CIN3: Grade 3 cervical intraepithelial neoplasia; ITT: Intention-to-Treat. Taken with permission from reference [21].
