| 20012601 |
The pharmacokinetic parameters of verapamil were significantly altered by the co-administration of lovastatin compared to the control |
Because of the words, “significantly,” (verapamil, lovastatin) is a DDI
|
| 20209646 |
The clearance of mitoxantrone and etoposide was decreased by 64 and 60 %, respectively, when combined with valspodar
|
Because the fold changes were less than 0.67 (mitoxantrone, valspodar) and (etoposide, valspodar) are DDIs
|
| 20012601 |
The (AUC (0-infinity)) of norverapamil and the terminal half-life of verapamil did not significantly changed with lovastatin co-administration |
Because of the words, “not significantly changed,” (verapamil, lovastatin) is an NDDI
|
| 17304149 |
Compared with placebo, itraconazole treatment significantly increases the peak plasma concentration (Cmax) of paroxetine by 1.3-fold (6.7 ±2.5 versus 9.0 ±3.3 ng/mL, p≤ 0.05) and the area under the plasma concentration–time curve from zero to 48 h (AUC(0–48)) of paroxetine by 1.5-fold (137 ±73 versus 199 ±91 ng×*h/mL, p≤0.01) |
AUC has a higher rank than Cmax, and it had a 1.5-fold change and less than 0.05 p-value; thus, (itraconazole, paroxetine) is a DDI
|
| 13129991 |
The mean (SD) urinary ratio of dextromethorphan to its metabolite was 0.006 (0.010) at baseline and 0.014 (0.025) after St John's wort administration (p= 0.26) |
The change in PK parameter is more than 1.5-fold but p-value is >0.05. Thus, (dextromethorphan, St John's wort) is an ADDI
|
| 19904008 |
The obtained results show that perazine at its therapeutic concentrations is a potent inhibitor of human CϒP1A2
|
Because of the word, “potent inhibitor,” (perazine, CYP1A2) is a DEI
|
| 19230594 |
After human hepatocytes were exposed to 10 μM ϒM758, microsomal activity and mRNA level for CϒP1A2 were not induced while those for CϒP3A4 were slightly induced
|
Because of the words, “not induced” and “slightly induced,” (YM758, CYP1A2) and (YM758, CYP1A2) are NDEIs
|
| 19960413 |
From these results, DPT was characterized to be a competitive inhibitor of CϒP2C9 and CϒP3A4, with K(i) values of 3.5 and 10.8 μM in HLM and 24.9 and 3.5 μM in baculovirus–insect cell-expressed human CYPs, respectively |
Because Kwzs larger than 10 μM, (DPT, CYP2C9) and (DPT, CYP3A4) are ADEIs
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