Table 3. Annotation performance evaluation.

Key terms	Annotation categories	Frequencies	Krippendorff's alpha
	Drug	8,633	0.953
	CYP	3,801
	PK parameter	1,508
	Number	3,042
	Mechanism	2,732
	Change	1,828
	Total words	97,291
DDI sentences	CDDI sentences	1,191	0.921
	VDDI sentences	120
	Total sentences	4,724
DDI pairs	DDI	1,239	0.905
	ADDI	300
	NDDI	294
	DEI	565
	ADEI	95
	NDEI	181
	Total drug pairs	12,399