| 1 |
There are multiple drugs and PK parameters in the sentence, and the sentence is long |
FP |
6 |
34 |
PMID: 12426514: In three subjects with measurable concentrations in the single-dose study, rifampin significantly decreased the mean maximum plasma concentration (C(max)) and area under the plasma concentration-time curve from 0 to 24 h (AUC(0–24)) of praziquantel by 81%(p<0.05) and 85 % (p<0.01), respectively, whereas rifampin significantly decreased the mean C(max) and AUC(0–24) of praziquantel by 74 % (p<0.05) and 80%(p<0.01), respectively, in five subjects with measurable concentrations in the multiple-dose study |
| FN |
2 |
17 |
PMID: 10608481: Erythromycin and ketoconazole showed a clear inhibitory effect on the 3-hydroxylation of lidocaine at 5 μM of lidocaine (IC50 9.9 μM and 13.9 μM, respectively) but did not show a consistent effect at 800 μM of lidocaine (IC50 > 250 μM and 75.0 μM, respectively) |
|
| 2 |
There is no direct DDI relationship between two drugs, but the presence of some words, such as dose and increase, may lead to a false-positive prediction |
FP |
6 |
14 |
PMID: 17192504: A significant fraction of patients to be treated with HMR1766 is expected to be maintained on warfarin |
|
| 3 |
DDI is presented in an indirect way |
FN |
2 |
19 |
PMID: 11994058: In CYP2D6 poor metabolizers, systemic exposure was greater after chlorpheniramine alone than in extensive metabolizers, and administration of quinidine resulted in a slight increase in CLoral |
|
| 4 |
Design issue: Some NDDIs are inferred due to some adjectives (little, minor, negligible) |
FP |
1 |
3 |
PMID: 10223772: In contrast, the effect of ranitidine or ebrotidine on CYP3A activity in vivo seems to have little clinical significance |
|
| 5 |
Unknown |
FP |
5 |
44 |
PMID: 10383922: CYP1A2, CYP2A6, and CYP2E1 activities were not significantly inhibited by azelastine and the two metabolites |
| FN |
6 |
26 |
PMID: 10681383: However, the most unusual result was the interaction between testosterone and nifedipine |
