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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Am J Transplant. 2015 Jun 23;15(11):2888–2899. doi: 10.1111/ajt.13368

Figure 3.

Figure 3

Nuclear ROS and interstitial fibrosis are increased after IRI. Semi-quantification of fluorescence intensity showed higher nuclear ROS 4 weeks after IRI compared to baseline. Similar findings were seen with Pircosirius Red staining (inserts show higher magnification). Nox −/− was associated with significant reduction in nuclear ROS and Fibrosis. The kidneys remarkably healed 6 months after IRI (n=3 for WT and KO at each time point). The Y axis in panel B is a ratio (no units) of pixels. Specifically, it represents the number of pixels for DHE staining divided by number of pixels in the total image.