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Gene groups of genes associated with hypoxia, oxidative stress, inflammation and fibrosis were increased by IRI. Heat maps of carefully curated gene groups were generated to show up- and down-regulation of transcripts associated with response to hypoxia, fibrosis and inflammation. Nox2−/− down-regulated transcripts associated with the same gene groups. Four animals in the WT-IRI group, 4 animals in the WT-t0 (baseline) group.
