Table 4.
Robust regression models for the change in TAC over time among participants with prevalent TAC at baseline.
| Variable | Robust Regression Model 1* (n=1578) | Robust Regression Model 2 (n=1550) | ||
|---|---|---|---|---|
| Difference in average progression (95% CI) | P value | Difference in average progression | P value | |
| Scanner type change | ||||
| EBCT to EBCT | Reference | |||
| EBCT to MDCT | −16.8 (−41,7.4) | 0.173 | −17 (−41.6, 7.5) | 0.174 |
| MDCT to MDCT | −23 (−31.7, −14.3) | <0.001 | −25.2 (−35.4, −15) | <0.001 |
| Follow-up time | 18.8 (13.8, 23.8) | <0.001 | 19.1 (14, 24.2) | <0.001 |
| Age (10 year) | 7.9 (2.5, 13.3) | 0.004 | 8.1 (2.4, 13.7) | 0.005 |
| BMI | 0.3 (−0.6, 1.2) | 0.512 | ||
| Systolic blood pressure (10 mm Hg) | 2.6 (0.6, 4.5) | 0.01 | 2.6 (0.7, 4.6) | 0.009 |
| Diastolic blood pressure (10 mm Hg) | 1.6 (−2.6, 5.7) | 0.465 | ||
| LDL-C (10 mg/dL) | −1.6 (−3, −0.2) | 0.028 | ||
| HDL-C (10 mg/dL) | −0.3 (−3.3, 2.7) | 0.838 | ||
| Log triglycerides (log mg/dL) | 4.0 (−4.4, 12.5) | 0.347 | ||
| Fibrinogen (mg/dL) | 0.1 (0.0, 0.1) | 0.048 | ||
| Log CRP (log mg/L) | 2.0 (−1.9, 5.8) | 0.316 | ||
| Male gender | −2.1 (−10.7, 6.5) | 0.632 | ||
| Race | ||||
| White | Reference | |||
| Chinese | −9.6 (−24.9, 5.7) | 0.217 | −5.9 (−21.5, 9.6) | 0.453 |
| African American | −9.7 (−21.1, 1.7) | 0.097 | −18.4 (−30.2, −6.6) | 0.002 |
| Hispanic | −14.8 (−27.2, −2.3) | 0.02 | −14.8 (−27.5, −2) | 0.023 |
| Education | ||||
| Less than high school | Reference | |||
| High school | −2.1 (−13.3, 9) | 0.706 | ||
| College | −9.1 (−23.7, 5.5) | 0.222 | ||
| Graduate school | −2.7 (−17.6, 12.2) | 0.723 | ||
| Income | ||||
| < 50,000 | Reference | |||
| 50,000–100,000 | 3.1 (−8.4, 14.7) | 0.593 | ||
| >100,000 | 3.5 (−8, 14.9) | 0.551 | ||
| Antihypertensive medication | 5.5 (−3.1, 14.1) | 0.212 | ||
| Lipid-lowering medication | 19.7 (9.8, 29.5) | <0.001 | 18.8 (8.8, 28.9) | <0.001 |
| Diabetes status | ||||
| Normal/ Impaired fasting glucose | Reference | |||
| Treated/Untreated Diabetes | 12.9 (1.2, 24.7) | 0.031 | 15.5 (3.5, 27.5) | 0.012 |
| Family history of heart attack | 6 (−2.9, 14.9) | 0.184 | ||
| Creatinine, mg/dL | ||||
| <=0.9 | −3.9 (−15.3, 7.6) | 0.505 | ||
| 1 | Reference | |||
| >=1.1 | −7.7 (−20.5, 5) | 0.236 | ||
| Alcohol | ||||
| Never | Reference | |||
| Former | −3.2 (−15.7, 9.4) | 0.621 | ||
| Currrent | −3.4 (−14.1, 7.4) | 0.54 | ||
| Smoking | ||||
| Never | Reference | |||
| Former | 5.8 (−4.6, 16.3) | 0.274 | 7.1 (−3.4, 17.5) | 0.184 |
| Current | 20.6 (4.6, 36.6) | 0.012 | 27 (10.9, 43) | 0.001 |
| 10 pack-years of smoking† | −0.5 (−2.1, 1.2) | 0.588 | −0.9 (−2.5, 0.8) | 0.302 |
*
Model 1 adjusted for scanner type change (EBCT to EBCT vs. EBCT to MDCT vs. MDCT to MDCT), age and follow-up time.
†
Model for pack-years also controls for smoking status (never, former, current).