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MALDI-QIT-TOF MS spectra show the difference of fucosylation in tri- and tetra-antennary N-glycans of haptoglobin between HCC (A) and cirrhosis (B). The elevated presence of bifucosylated tri- and tetra-antennary glycans in HCC samples compared with cirrhosis is highlighted with a red rectangle. The enlarged inset shows two peaks of the bifucosylated tri- (m/z 2867.48) and tetra-antennary (m/z 3316.69) N-glycans, which are highly associated with HCC.
