Figure 1. CSE preparation and endothelial viability assessment following antioxidant treatments.
Panel A) Concentrated Smoke Extract (CSE) preparation by a Single Cigarette Smoking Machine according to ISO/FTC protocol. (Puff volume- 35ml, duration-2s, interval-58s; 8 puffs/cigarette); Smoking protocol is computer controlled. Panel B) results from the lactate dehydrogenase (LDH) assay using the Pierce™ LDH cytotoxicity kit. No significant change in LDH release was observed in all exposure conditions in comparison to the control. Microscopic images of intact monolayers of hCMEC/D3 cells after treatments. n = 5 biological replicates.