Table 1.

Echocardiographic Measurements at 12 Weeks of Age

	CTL n=6	CSN8^hypo n=8	CTL::CryAB^R120G n=10	CSN8^hypo::CryAB^R120G n=8
Body weight (g)	30.4±2.1	27.2±3.5	28.2±3.7	28.8±4.2
Heart rate (bpm)	471±24	487±42	432±43	472±43
LVIDd (mm)	4.37±0.35	4.09±0.14	3.90±0.26^†	3.54±0.28^†^‡
LVPWd (mm)	0.70±0.13	0.73±0.13	0.93±0.15^†	0.88±0.06^*
LVIDs (mm)	3.17±0.26	3.12±0.21	2.45±0.22^†	1.89±0.22^†^‡
LVPWs (mm)	1.13±0.12	1.09±0.24	1.45±0.27^†	1.44±0.14^†
LVAWd (mm)	0.71±0.08	0.67±0.12	1.00±0.20^†	0.97±0.19^†
LVAWs (mm)	1.15±0.12	1.03±0.27	1.52±0.25^†	1.55±0.21^†
LV FS (%)	30.02±2.48	28.59±2.00	37.84±5.93^*	45.07±4.11^†^‡
LV EF (%)	53.83±5.68	58.55±5.52	65.19±8.95^*	77.25±4.20^†^‡
LVVd (mm³)	87.58±15.20	77.33±2.40	66.20±10.92^†	49.59±11.02^†^‡
LVVs (mm³)	40.28±8.18	41.29±6.18	22.28±9.46^†	11.31±3.41^†^‡
SV (µl)	47.3±10.3	35.2±6.2	43.9±6.7	38.3±8.6
CO (ml/min)	22.3±4.9	17.2±3.9	19.0±4.3	18.1±4.2

LVIDd, end-diastolic left ventricular (LV) internal diameter; LVIDs, end-systolic LVID; LVPWd, end-diastolic LV posterior wall thickness; LVPWs, end-systolic LVPW; LVAWd, end-diastolic LV anterior wall thickness; LVAWs, end-systolic LVAW; FS, fractional shortening; EF, ejection fraction; LVVd, end-diastolic LV volume; LVVs, end-systolic LVV; SV, stroke volume; CO, cardiac output.

p<0.05,

^†

p<0.01 vs. CTL;

^‡

p<0.05 vs. CTL::CryAB^R120G; ANOVA followed by the Scheffé test.