. Author manuscript; available in PMC: 2016 Nov 4.

Published in final edited form as: J Ethnopharmacol. 2015 Aug 7;174:57–65. doi: 10.1016/j.jep.2015.08.006

Table 2.

Cannabinoid and opioid receptor displacements of extract, partitions, and compounds of N. nucifera flowers.

Extracts/ partitions/ compounds	CB receptor displacement (%) (10 µg/mL)		Opioid receptor displacement (%) (10 µg/mL)
Extracts/ partitions/ compounds	CB1	CB2	δ	κ	μ
N. nucifera (white flower) EtOH extract	17	14	13	46	-
N. nucifera (pink flower) EtOH extract	4	7	25	54	-
N. nucifera (white flower) basic CHCl₃ partition	-	5	71	91	91
N. nucifera (pink flower) basic CHCl₃ partition	26	26	53	95	96
N. nucifera (white flower) acidic CHCl₃ partition	2	12	14	18	20
N. nucifera (pink flower) acidic CHCl₃ partition	37	34	18	15	26
Fraction G (PA:LA; 63.9:36.1)^a	6	12	91	51	87
Fraction H (PA:LA; 89.5:10.5)^a	17	-	64	19	24
Armepavine (4)	-	14	46	66	65
O-Methylcoclaurine (5)	-	30	49	83	85
N-Methylcoclaurine (6)	-	13	55	92	83
Coclaurine (7)	15	8	51	91	83
Neferine (10)^b	-	-	88	91	93
Linoleic acid (LA)^b	30	14	60	19	34
Palmitic acid (PA)^b	16	19	57	9	16
LA + PA (1:1 mixture)	4	7	96	50	69
CP-55,940^b	96	100	-^c	-^c	-^c
Naloxone HCl^b	-^c	-^c	100	100	101

Palmitic and linoleic acid mixture analyzed by GC/MS;

Tested at 10 µM,

Not applicable,

-: Not active