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. Author manuscript; available in PMC: 2017 May 5.
Published in final edited form as: Eur J Pharmacol. 2015 May 7;778:44–55. doi: 10.1016/j.ejphar.2015.04.045

Table 1.

Disease associations

Tryptases
  Anaphylaxis (Caughey, 2006; Schwartz, 2006)
  Asthma (Cairns, 2005; Chen et al., 2006; Costanzo et al., 2008; Krishna et al., 2001)
  Allergic rhinitis (Erin et al., 2006; Takabayashi et al., 2012)
  Eosinophilic esophagitis (Abonia et al., 2010)
  Inflammatory bowel disease (Hamilton et al., 2010; Hansbro et al., 2014; Isozaki et al., 2006; Tremaine al., 2002)
  Arthritis (Shin et al., 2009)
  Cigarette-associated lung and airway disease (Beckett et al., 2013; Hansbro et al., 2014)
  Allergic skin disease (Järvikallio et al., 1997)
  Bacterial infection (protective) (Thakurdas et al., 2007)
  Aortic aneurysm (Zhang et al., 2011)
Chymases
  Systemic arterial hypertension (Ju et al., 2001; Koga et al., 2003; Wei et al., 2010)
  Ischemia-reperfusion injury (Abonia et al., 2005; Jin et al., 2001; Morikawa et al., 2005; Pat et al., 2010)
  Fibrosis: skin, lung, kidney, heart, liver (Cha et al., 2012; Shiota et al., 1997; Tchougounova et al., 2005)
  Pulmonary artery hypertension (Kosanovic et al., 2014; Wang et al., 2010)
  Asthma (protective) (Balzar et al., 2005; Sugimoto et al., 2012; Waern et al., 2009)
  Envenomation (protective) (Akahoshi et al., 2011)
  Intestinal parasitosis (protective) (Knight et al., 2000)
  Skin malignancy (Coussens et al., 1999)
  Aortic aneurysm (Furubayashi et al., 2008; Inoue et al., 2009; Sun et al., 2009)
Carboxypeptidase A3
  Envenomation (protective) (Metz et al., 2006)
Cathepsin C/Dipeptidylpeptidase I
  Septic peritonitis (Mallen-St Clair et al., 2004)
  Gram-negative pneumonia (Sutherland et al., 2014)
  Periodontitis/Papillon-Lefevre syndrome (Pham et al., 2004)