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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Biol Psychiatry. 2015 May 7;79(11):878–886. doi: 10.1016/j.biopsych.2015.04.026

Figure 6.

Figure 6

Adolescent dopamine-like neurons are associated with weaker adaptation to extinction. (A) Adult dopamine-like cue-evoked responses decrease magnitude more completely than those of adolescent neurons. Each panel depicts the normalized neuronal responses of dopamine-like neurons in both age groups. Data are displayed for sessions 7 and 8. Session 7 was divided into a block of reinforced actions (session 7R, 30 trials, top row) and a block of trials in which actions were no longer reinforced (session 7E, 30 minute block, middle row). Session 8 contained only trials in which actions were never reinforced (30 minute session, bottom row). Data are depicted similarly to Figures 2 and 4. The blue overlay depicts data from extinction trials. In extinction trials, data in the right column are aligned to the time that rewards were formerly delivered, but now withheld. (B) Adult evoked neuronal responses are of smaller magnitude than those of adolescents during extinction. Normalized neural activity of dopamine-like neurons is displayed for a window of time just prior to cue onset (−1.5 – −1.2 sec) and just after cue onset (0 – .3 sec). Data are displayed as the mean + SE across all trials and neurons.