Table 3.
Sensitivity analyses; adjusted∗ risk ratios for a one-unit increase in exposure.
| Sensitivity analysis description | aRR∗ (95% CI) | ||
|---|---|---|---|
| Most recent VL | Viremia since ART | Viremia in two years | |
| Original | 1.17 (1.01, 1.35) | 0.80 (0.69, 0.92) | 1.00 (0.90, 1.11) |
| Restricted to exposure after 1998 and adjusted for HAART | 1.27 (1.07, 1.50) | 0.99 (0.82, 1.17) | 0.97 (0.83, 1.13) |
| Dropped VL at ART initiation | N/A | 0.83 (0.68, 1.03) | N/A |
| Adjusted for time on ART | N/A | 0.80 (0.68, 0.95) | N/A |
| Only included VL during pregnancy | 1.10 (0.87, 1.39) | N/A | N/A |
| Time frame changed to one year | N/A | N/A | 0.87 (0.75, 1.00) |
| Time frame changed to three years | N/A | N/A | 0.97 (0.87, 1.09) |
| Excluded stillbirths | 1.18 (1.01, 1.38) | 0.80 (0.69, 0.93) | 0.99 (0.88, 1.12) |
| Modification by CD4 | |||
| CD4 ≤ 500 | 1.15 (0.99, 1.33) | 0.81 (0.68, 0.97) | 0.94 (0.82, 1.07) |
| CD4 > 500 | 1.17 (0.95, 1.43) | 0.81 (0.67, 0.98) | 1.16 (0.98, 1.36) |
| Adjusted for CD4 nadir | 1.18 (1.03, 1.35) | 0.79 (0.69, 0.91) | 1.02 (0.91, 1.14) |
aRR = adjusted risk ratio, ART = antiretroviral therapy, HAART = highly active antiretroviral therapy, and VL = viral load.
∗Adjusted for maternal age (with a linear spline at age 35), race, income, prior pregnancy loss, smoking, noninjection drug use, CD4 count at baseline, and ART use at baseline (separately controlling for mono-/dual and HAART versus none).