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. 2015 Oct 25;2015:979645. doi: 10.1155/2015/979645

Table 2.

Exercise-induced changes in NK-cell subset numbers in healthy adult males (N CMV+ = 20; N CMV− = 20) contrasted by CMV serostatus and age. CMVpos and CMVneg participants are denoted by + and −, respectively. Main and interaction effects for CMV, age, and time are reported with significance connoted by ∗(p < 0.05). Statistical differences from pre- and 1 h post-values are described by # and ∧, respectively (p < 0.05). Data are mean ± SD.

NK-Cell subsets CMV status Pre-values Post-values 1 h post-values Main effects
F statistic (p value)		 Interactions
F statistic (p value)
Time Age CMV Time × Age Time × CMV Age × CMV Time × Age × CMV
Total NK-cells/μL     #∧ # 157.7∗ (<0.001) 2.6 (0.108) 5.7∗ (0.019) 0.6 (0.557) 4.7∗ (0.019) 1.3 (0.252) 1.0 (0.357)
Younger
(23–39 yrs)		 − 166 ± 96 785 ± 337 130 ± 117              
+ 181 ± 97 595 ± 360 128 ± 84              
Older
(50–64 yrs)		 − 223 ± 56 987 ± 182 142 ± 57              
+ 189 ± 85 666 ± 242 153 ± 69              
CD56dim (cells/μL)     #∧ # 157.1∗ (<0.001) 2.8 (0.085) 5.6∗ (0.020) 0.7 (0.518) 4.7∗ (0.018) 1.7 (0.197) 1.1 (0.333)
Younger
(23–39 yrs)		 − 147 ± 91 738 ± 325 106 ± 100              
+ 162 ± 94 556 ± 357 112 ± 82              
Older
(50–64 yrs)		 − 205 ± 58 942 ± 184 125 ± 57              
+ 176 ± 79 631 ± 217 135 ± 54              
CD56 bright (cells/μL)     #∧   25.2∗ (<0.001) 1.1 (0.291) 2.5 (0.114) <0.1 (0.999) 0.4 (0.687) <0.1 (0.834) 0.5 (0.636)
Younger
(23–39 yrs)		 − 19 ± 12 47 ± 27 24 ± 22              
+ 19 ± 9 39 ± 15 16 ± 7              
Older
(50–64 yrs)		 − 18 ± 9 45 ± 23 17 ± 6              
+ 13 ± 10 35 ± 31 18 ± 15              
KLRG1+ (cells/μL)     #∧   72.6∗ (<0.001) 0.1 (0.773) 2.1 (0.153) 0.1 (0.929) 1.1 (0.335) 0.1 (0.788) 0.1 (0.948)
Younger
(23–39 yrs)		 − 98 ± 76 493 ± 240 80 ± 73              
+ 84 ± 70 334 ± 284 56 ± 64              
Older
(50–64 yrs)		 − 111 ± 45 481 ± 149 78 ± 13              
+ 95 ± 64 398 ± 198 69 ± 44              
CD57+ (cells/μL)     #∧   98.5∗ (<0.001) 5.3∗ (0.023) 5.2∗ (0.024) 1.7 (0.196) 2.5 (0.084) 2.7 (0.105) 1.0 (0.360)
Younger
(23–39 yrs)		 − 63 ± 39 335 ± 190 53 ± 49              
+ 74 ± 48 310 ± 184 50 ± 32              
Older
(50–64 yrs)		 − 125 ± 29 578 ± 146 87 ± 29              
+ 110 ± 46 453 ± 109 80 ± 29              
CD158a+ (cells/μL)     #∧   50.7∗ (<0.001) 0.9 (0.349) 2.7 (0.103) 0.3 (0.717) 1.3 (0.284) 0.2 (0.698) <0.1 (0.980)
Younger
(23–39 yrs)		 − 40 ± 25 228 ± 191 31 ± 34              
+ 40 ± 20 179 ± 87 28 ± 19              
Older
(50-64 yrs)		 − 51 ± 37 277 ± 91 32 ± 28              
+ 25 ± 16 119 ± 97 17 ± 15              
CD8+ (cells/μL)     #∧   79.4∗ (<0.001) 8.4∗ (0.004) 1.2 (0.269) 2.7 (0.069) 1.7 (0.193) 4.8∗ (0.031) 3.0 (0.052)
Younger
(23–39 yrs)		 − 51 ± 35 184 ± 126 45 ± 46              
+ 61 ± 37 210 ± 94 42 ± 28              
Older
(50–64 yrs)		 − 94 ± 36 406 ± 159 62 ± 21              
+ 62 ± 43 200 ± 75 39 ± 22