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The schematic presentation of two glutamine metabolism pathways: glutaminolysis and reverse TCA and its connection with the Acetyl-CoA pump that transports Acetyl-CoA from mitochondria to cytoplasm. In the case of deteriorated PDHC6 activity as in majority of cancers, the carbon skeleton of GLN can be metabolized only to lactate or alanine. The other pathways are rather negligible.
